• Initial studies generally focused on the

  2022-04-06

  

  Initial studies generally focused on the co-administration of glutamate with transport inhibitors and clearly revealed the ability of the blockers to exacerbate excitotoxic injury in both in vitro and in vivo models (McBean & Roberts, 1985, Robinson et al., 1993a). In addition to demonstrating the c

• The ion conduction pathway reported herein

  2022-04-06

  

  The ion conduction pathway reported herein accounts for all known functional properties of EAAT/GltPh anion channels. Simulations reveal unitary current amplitudes and ion selectivities (Figures 3C and 3D) that resemble experimental results (Melzer et al., 2003, Wadiche and Kavanaugh, 1998). The cal

• Overnight mg dexamethasone suppression testing DST of the Bc

  2022-04-06

  

  Overnight 1-mg dexamethasone suppression testing (DST) of the BclI polymorphism carriers found them to have lower cortisol levels, suggesting an increased sensitivity to GCs with respect to the transrepression effect of cortisol on the POMC gene of the corticotroph pituitary cells [28]. The exact me

• br Acknowledgements This work was supported by a

  2022-04-06

  

  Acknowledgements This work was supported by a fellowship to C.H. under the ‘100 Foreign Expert’ scheme of the Shanxi province government(R100456). Conflict of interest: Dr. Holscher is a named inventor on a patent submitted by Lancaster University on the use of dual GLP-1/GIP analogues in neurode

• br Conflict of interest br

  2022-04-06

  

  Conflict of interest Introduction Since its discovery in 1958 [1]the Ca2+-dependent K+ efflux in human red blood Ademetionine synthesis (RBC) (further referred to as the Gárdos effect) has been extensively studied (see 2, 3for review) and has been helpful in understanding the role of the Ca2+

• br Ethics approval br Availability of data and materials

  2022-04-06

  

  Ethics approval Availability of data and materials Consent for publication Competing interests Authors contributions Introduction Glucose supply to tissues is maintained through a complex regulatory network mostly driven by the pancreatic hormones insulin and glucagon which contro

• In summary although there are still several important questi

  2022-04-02

  

  In summary, although there are still several important questions open on the mechanisms that trigger FAK nuclear localization and FAK-dependent gene regulation, Cardoso et al. (2016) provide important new insights on FAK/MEF2-mediated initiation of cardiac hypertrophy. Acknowledgments The author

• br Methods br Results br Discussion In

  2022-04-02

  

  Methods Results Discussion In the general population BNP has been established as a marker for Dimesna failure diagnosis. Moreover, there is growing evidence that elevated levels of natriuretic-peptides may improve CV risk prediction in the general population above traditional risk factors

• br Expression and Purification of LSD Proteins

  2022-04-02

  

  Expression and Purification of LSD1 Proteins In Vitro Enzymatic Assays Analysis of LSD1 Demethylase Activity Acknowledgments Conflict of Interest Statement: Y.S. is a cofounder of Constellation Pharmaceuticals, Inc. and is a member of its scientific advisory board. Y.S. is also a consu

• br Materials and methods br

  2022-04-02

  

  Materials and methods Results Discussion Type I ECa is associated with estrogen excess, obesity and hormone-receptor positivity. However, the function of ERα on ECa is considered complicated. The expression of ERα is reduced in grade III ECa clinical samples [13]. The high ERα expression is

• br Conclusion H R H R and H R

  2022-04-02

  

  Conclusion H1R, H2R, and H3R mRNAs were expressed in rat OE. Moreover, these three histamine receptors were present in the cytoplasm of ORNs in OE. This is the first report of the expression and localization of histamine receptors in mammalian OE. These findings indicate that histamine may play a

• These agents can be divided into three categories based

  2022-04-02

  

  These agents can be divided into three categories based upon the therapeutic agent conjugated to the antibody; the most frequently explored are ADCs using a cytotoxic agent to be delivered directly to the tumor site. The second class has not been broadly used and consists of radionucleotides (Wong e

• Thus one of the aim of

  2022-04-02

  

  Thus, one of the aim of the work was to link the phytotoxic effect of m-Tyr on root growth of tomato seedlings to modification of RNS level and tissue distribution accompanied by determination of 3-NT content. Due to the role of GSNOR, which is suggested to be a key element in the interplay between

• Several studies have sought a cross relationship between

  2022-04-02

  

  Several studies have sought a cross-relationship between commensal bacteria-derived metabolites and the Gprs (Blad et al., 2012). Gpr81 is expressed primarily in adipocytes, and hence, lactate-Gpr81 interaction inhibits lipolysis (Cai et al., 2008, Liu et al., 2009). Lactate reduced inflammation by

• Structural analysis of the MD open

  2022-04-01

  

  Structural analysis of the MD-open state unveils that the transmembrane domain features a symmetric organization of the pore-lining helices M2 similar to the semi-open structure but with a local asymmetry at the constriction point, which is critical for chloride permeation. The atomistic simulations

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