• No vaccines and antiviral drugs are currently available to

  2018-11-07

  

  No vaccines and antiviral drugs are currently available to prevent and treat ZIKV infection. Animal models are essential for the development of such countermeasures. Young A129 mice (lacking interferon α/β receptor) and AG129 (lacking interferon α/β and γ receptors) were recently reported to succumb

• This simple message of assessing the

  2018-11-07

  

  This simple message of assessing the fall status in all preoperative patients will hopefully be adopted in daily clinical practice. Early identification of patients at risk of postoperative falls may enable preventative measures to be implemented before surgery to decrease the risk of postoperative

• The succesful development of flavivirus vaccines began

  2018-11-07

  

  The succesful development of flavivirus vaccines began 80years ago in 1937 with the yellow fever YFV17D live-attenuated vaccine (Monath, 2008). Since then, >600 million people have been vaccinated, with 98% protection and a >10year persistence of vaccine–induced immunity (Barrett and Teuwen, 2009).

• Other studies have examined the utility

  2018-11-07

  

  Other studies have examined the utility of absolute blood counts in predicting survival of advanced melanoma patients. In a cohort of patients with stage III–IV melanoma treated with surgical resection, absolute lymphocyte count (ALC), a component of NLR, was associated with PFS but not OS in stage

• There remains a technical problem with a large amount of

  2018-11-07

  

  There remains a technical problem with a large amount of input DNA and/or poor quality DNA. The number of false positive events for some assays is increased by poor discrimination of the end point signal from other clusters within a 2-dimensional histogram in a multiplex assay. The insufficient sepa

• To improve peptide spectral matching sensitivity

  2018-11-07

  

  To improve peptide-spectral matching sensitivity and accuracy in obtaining MS2 peptide identification and spectral count quantitation mass spectra were searched using 3 search engines: Tide, INSPECT and MSGFDB each employing a different search methodology, and the spectral counts were integrated pro

• br Value of the data

  2018-11-07

  

  Value of the data Data This dataset collates the comprehensive proteomic data generated through a SILAC-based quantitative MS approach upon silencing the 65 tyrosine kinases expressed in MCF7 breast cancer Madecassic acid manufacturer [1]. In addition to the raw data files deposited in the Pr

• In the melting experiments with NMM and PDS

  2018-11-07

  

  In the melting experiments with NMM and PDS (Figs. 3 and 4), the ligands were added to pre-annealed ON solutions, and ON CD at 265/295nm was registered every 1°C across the 20–90°C temperature range. The heating rate was 1°C /min. The melting temperatures of GQs/imGQs were defined by performing a fi

• Metaplasticity is the dynamic regulation of the ability

  2018-11-07

  

  Metaplasticity is the dynamic regulation of the ability to induce activity-dependent synaptic plasticity and is governed by the prior history of activity (i.e. the plasticity of synaptic plasticity, Abraham and Bear, 1996). In empirical tests, synaptic metaplasticity is commonly defined as a shift i

• Finally there are questions concerning cognitive interpretat

  2018-11-07

  

  Finally, there are questions concerning cognitive interpretations that are routinely assigned to resting-state networks. Because profiles of activity that correlate with the instantiation of cognitive control (i.e., task-based maps of the CCN) appear convergent with maps of the CCN generated from re

• br Conclusions Although we have

  2018-11-07

  

  Conclusions Although we have focused specifically on cortical and hippocampal learning systems, there are other learning systems in the mitotic inhibitor that may relate to memory development. One important system includes the basal ganglia, which are highly responsive to reward and function as a

• To elucidate the development of neural mechanisms mediating

  2018-11-07

  

  To elucidate the development of neural mechanisms mediating age-related changes in behavior, it PR619 is important to map brain-behavior associations across age (Pfeifer and Allen, 2012). Poldrack has emphasized the importance of quantifying such associations precisely (Poldrack, 2014). However, mo

• In human adults the mu rhythm is sensitive to observation

  2018-11-07

  

  In human adults, the mu rhythm is sensitive to observation and mental imagery of orofacial movements (Muthukumaraswamy et al., 2006; Pfurtscheller et al., 2006; Spiegler et al., 2004), and the few studies that have investigated adult mu activity during observation of emotional facial expressions su

• br The Breadth of affect biased attention The proposed model

  2018-11-07

  

  The Breadth of affect-biased attention The proposed model accounts for the fact that while a perceptual sensitivity to particular cues may be normative and adaptive, displaying a large and fixed attention bias may be associated with psychopathology. For instance, in the anxiety literature, a perc

• br SES language and brain

  2018-11-07

  

  SES, language, and brain structure The brain undergoes significant changes over the course of development (Johnson et al., 2016). Synaptic density increases rapidly in the first few years of life, during which time neurons form connections and become organized into specialized functional regions.

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