• Introduction Obesity is a metabolic disorder and can be defi

  2018-11-12

  

  Introduction Obesity is a metabolic disorder and can be defined as increased body weight caused by excessive fat accumulation which presents a risk to health with an increase in health problems and/or reduced life expectancy [1,2]. Obesity is characterized by an increased storage of triglycerides i

• We demonstrated that the PI K AKT

  2018-11-12

  

  We demonstrated that the PI3K/AKT signaling pathway plays important roles in regulating hUCBSC differentiation and maintaining the pluripotency of hESCs (Yu et al., 2012). Furthermore, mTOR/p70S6K, a major downstream effector of PI3K/AKT signaling, was found to be phosphorylated, suggesting that HMG

• Our ChIP seq data indicate that Cdx and Sall engage

  2018-11-12

  

  Our ChIP-seq data indicate that Cdx4 and Sall4 engage in auto- and cross-regulatory loops. Such regulatory circuits are frequently seen during embryonic development. For example, during segmentation of rhombomere 4 in the mouse hindbrain, retinoic orexin cost signaling first turns on HoxB1, followed

• br Materials and methods br Results br Discussion

  2018-11-12

  

  Materials and methods Results Discussion Using a dual-promoter lentivirus-transduced BM-HSC transplantation model, we report here that both transgenes (i.e. murine invariant chain (Ii) and the GFP reporter) can be detected in various APC cell types from different organs (Fig. 1). Thus, this

• In the present experiments we tested the

  2018-11-12

  

  In the present experiments, we tested the general applicability of the previously developed neural differentiation protocol in 3 different marmoset iPS cell lines. As expected, the protocol worked efficiently for the cell line on which it was originally developed, but it worked much less well on the

• Paradoxically we found that mutant K Ras

  2018-11-12

  

  Paradoxically, we found that mutant K-Ras increases proliferation of quiescent intestinal stem CA-074 Me (Fig. 2), but also increases repair following damage (Fig. 3). This phenomenon is similar to the role that oncogenic N-Ras plays in hematopoietic stem cells (HSCs) (Li et al., 2013). In this con

• In the present experiments we tested the

  2018-11-12

  

  In the present experiments, we tested the general applicability of the previously developed neural differentiation protocol in 3 different marmoset iPS cell lines. As expected, the protocol worked efficiently for the cell line on which it was originally developed, but it worked much less well on the

• We have recently developed a new

  2018-11-12

  

  We have recently developed a new cell delivery system that enabled the transplantation of hBM-MSCs as a thin layer across the extravascular spaces of the choroid in RCS rats. The graft covered most of the area of the back of the eye via a single injection with no retinal detachment or choroidal hemo

• Research in the field of child spiritual health

  2018-11-09

  

  Research in the field of child spiritual health is challenged by the multidisciplinary nature of the concept and the fact that there are subtle differences in language and definitions applied across disciplines, and approaches to presentation of findings. Child spirituality has been referred to as a

• Introduction Attention mechanisms play an early and pervasiv

  2018-11-09

  

  Introduction Attention mechanisms play an early and pervasive role in shaping behavior. Historically, much of the literature has focused on cognitive or “cool” components of attention development and functioning. Thus we have a strong literature order Staurosporine examining, for example, the impa

• However Ae albopictus was responsible for the epidemic trans

  2018-11-09

  

  However, Ae. albopictus was responsible for the epidemic transmission of chikungunya, an alphavirus, in Italy 2007 (Carrieri et al., 2011). Therefore, it is unlikely that at that time factor 1) - insufficient Ae. albopictus population - is the main reason for not having dengue outbreaks in Europe, u

• Stratifying patients according to the toxicity risk and modu

  2018-11-09

  

  Stratifying patients according to the toxicity risk and modulating EBRT dose would provide a valuable tool for personalized EBRT (). Many efforts have been made to develop assays capable of predicting susceptibility for the development of radiation injury that finally allow customization of EBRT pro

• In conclusion this translational investigation

  2018-11-09

  

  In conclusion, this translational investigation identified gene candidates, including Marco, for host susceptibility to multiple phenotypes of RSV disease in mice that closely mimic human disease, and a polymorphism in human MARCO associated with increased risk of RSV disease severity in infants. Co

• In conclusion this translational investigation

  2018-11-09

  

  In conclusion, this translational investigation identified gene candidates, including Marco, for host susceptibility to multiple phenotypes of RSV disease in mice that closely mimic human disease, and a polymorphism in human MARCO associated with increased risk of RSV disease severity in infants. Co

• br Introduction MicroRNA miRNAs are a class of endogenous

  2018-11-09

  

  Introduction MicroRNA (miRNAs) are a class of endogenous and non-coding single-stranded RNAs of approximately 22 nucleotides (Bartel, 2004), many of which are evolutionarily conserved (Farh et al., 2005). Nucleotides 2–7, from the 5′ end of the miRNA, are referred to as the seed sequence and are

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