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Ten years ago Shinya Yamanaka and
2018-11-05
Ten years ago Shinya Yamanaka and colleagues from Kyoto University (Japan) described the creation of induced pluripotent stem rsv virus (iPSCs), first from mice, then humans a year later. The ability to ‘reprogram’ mature cells into iPSCs by introducing genes that encode specific transcription fact
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The high burden of ocular
2018-11-05
The high burden of ocular disease in CKD can be explained, in part, by the sharing of risk factors common to both kidney and eye diseases such as age, smoking, hypertension, diabetes, raised serum cholesterol and obesity. Ocular diseases may also be directly linked to CKD via common pathogenic pathw
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There are a number of reasons
2018-11-05
There are a number of reasons that make the possibility to use blood-based miRNA signatures as diagnostic tools very attractive: i) cancer can be diagnosed in a minimally invasive way through a simple blood test; ii) a blood test does not require hospitalization and the access to complex and expensi
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Barry and colleagues have successfully used sophisticated
2018-11-05
Barry and colleagues have successfully used sophisticated and demanding in vivo recording techniques to correlate behavior and Madecassoside function at the mesoscale level. This is but one example of the power of those techniques that attempt the difficult task of bridging the behavior of single c
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In their manuscript in Psomas
2018-11-05
In their manuscript in , Psomas and colleagues used a combination of 68 markers of immune activation and inflammation and two independent hierarchical clustering analyses to identify 5 donor groups from among 120 HIV-infected virologic responders (). These donor groups were characterized using combi
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br Heating Up Immunologically Cold
2018-11-05
Heating Up Immunologically Cold Tumours With an Oncolytic Virus As discussed our immune systems have evolved elaborate mechanisms to react against invading pathogens and rapidly mount immune responses to eliminate the pathogen and in some instances, the cells they infect. OVs are natural pathogen
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A potential limitation of our
2018-11-05
A potential limitation of our study was the use of hospital controls as proxies of healthy people. Controls were admitted for a wide variety of routine conditions unrelated to tobacco and it is implausible that a high proportion of the controls with a detectable damaging TP53 mutation developed a ca
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The authors identified other genetic
2018-11-05
The authors identified 13 other genetic variants that are promising candidates. None of these additional genetic variants reached the pre-specified level of statistical significance and therefore do not meet the discovery threshold but remain as promising candidates requiring further work and valida
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br Introduction In order to obtain easy access to
2018-11-05
Introduction In order to obtain easy access to accurate material and rsk inhibitor inventory data for the modelling of industrial bioprocesses at the early stages of process design, a Microsoft® Excel model has been developed, termed the CeBER Bioprocess Modeller (Centre for Bioprocess Engineeri
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OAs can be divided into two groups
2018-11-05
OAs can be divided into two groups: mandibular advancement devices (MADs), which are attached to the teeth and move the mandible anteriorly, and tongue retaining devices, which use suction to position the tongue anteriorly inside a bulb [5]. MADs have higher success and compliance rates than tongue
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lxr agonists At a later point of
2018-11-05
At a later point of time, when the fastest arriving stimulus used in a previous associative learning event reaches the nervous system, it reactivates the IPL and activates the inter-LINKed postsynaptic terminal from a lateral direction (Fig. 1D). When the postsynaptic terminal is in a background sta
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Prather in a recent study on
2018-11-05
Prather [14], in a recent study on 164 healthy subjects experimentally exposed to rhinovirus, observed through pulse actigraphy that those with fewer than six hours of sleep, before exposure, were four times more likely to become sick (9h), presented a risk of 1.39 (95%; 1.06–1.82) and 1.38 (95%; 1.
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Here is the birefringence of the fiber z is
2018-11-05
Here , , Δβ is the birefringence of the fiber, z is the twisted fiber length, α is the strain induced optical rotation which is proportional to θ and given as: α=gθ, where g is a constant which depends on the photoelastic coefficients of the material. When the fiber is twisted, the fringe will be sh
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br Methods The list of
2018-11-05
Methods The list of used reagents can be found in Supplementary information. Results and discussion Conclusion We have devised a novel gold nanoparticle based colorimetric GS-9620 for the detection of E. coli bacteria in urine of UTI patients. The sensor was constructed by conjugating cyst
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Notably some FoDHs in the metal containing FoDH
2018-11-05
Notably, some FoDHs in the metal-containing FoDH class also comprises NAD-linked FoDH, which contains FMN to link with NAD+. These enzymes utilize NAD+ only as the GSK126 acceptor in the biological system. These enzymes are suitable for electrochemistry because some of them can transfer electrons t
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