trifluoperazine br Conclusion In summary we provided the fir

2018-10-20

Conclusion In summary, we provided the first evidence that FOXM1 plays an important role in the maintenance of cell proliferation in the hESC cell line VAL-3, with significant functions in safe-guarding progression through G2/M phase mediated by the transcriptional regulation of trifluoperazine

Our work has also helped clarify

2018-10-20

Our work has also helped clarify the role for ATM in human cell telomere maintenance specifically in the context of reprogramming. The observations of accelerated telomere shortening (Metcalfe et al., 1996; Xia et al., 1996) and spontaneous telomere fusions in primary (Kojis et al., 1989, 1991) and

br Material and methods br Results br Discussion Pre

2018-10-20

Material and methods Results Discussion Pre-transplant myeloablation has been consistently seen to be associated with an increase in the number of adipocytes in the bone marrow (Snyder, 1965; Naveiras et al., 2009; Cao et al., 2011). These marrow adipocytes were considered as passive space

br Experimental Procedures br Author Contributions

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Recently, substantial progress has been made to elicit organogenesis in 3D culture (Antonica et al., 2012; Huch et al., 2013; Liu et al., 2010; Sato et al., 2009; Spence et al., 2011). In the neural lineage, embryo

The role of PGRN in cortical

2018-10-20

The role of PGRN in cortical neurons is currently not well understood. PGRN exerts neurotrophic properties through a yet-unidentified receptor (De Muynck et al., 2013; Gass et al., 2012; Van Damme et al., 2008). However, a strong link between PGRN and the WNT signaling pathway in neuronal physiology

br Resource table Resource details

2018-10-20

Resource table. Resource details Macaca fascicularis iPS cftr inhibitor ATCi-MF1 were generated from adult skin-derived fibroblasts by transduction with non-integrative Sendai viruses coding for the reprogramming factors OCT3/4, KLF4, SOX2 and c-MYC (Ban et al. 2011; Zapata-Linares et al. 2016)

Partial cleavage of CXCL at

2018-10-20

Partial cleavage of CXCL12 at the N-terminus by distinct peptidases results in loss of chemotactic activity and impairment in CXCR4 receptor affinity (Cho et al., 2010; Delgado et al., 2001; Levesque et al., 2003). The proteolytic cleavage of CXCL12 by matrix metalloproteinase 2 and 9 (MMP-2 and 9)

br Introduction Visional signals are

2018-10-20

Introduction Visional signals are mediated by photoreceptors, bipolar nucleoside analog and ganglion cells, and the loss of these neurons leads to irreversible blindness (de Jong, 2006; Friedman et al., 2004; Hartong et al., 2006; Quigley and Broman, 2006; Ramsden et al., 2013; Thylefors et al.,

WNT signaling is well recognized for its role in

2018-10-20

WNT signaling is well recognized for its role in regulating stem and progenitor lp-pla2 inhibitor in diverse systems (Nusse et al., 2008). Elevated levels of β-catenin, indicative of aberrant WNT signaling, are reported in more than 50% of human breast carcinomas, correlate with poor prognosis, and

br Results br Discussion FLT and KIT

2018-10-20

Results Discussion FLT3 and KIT are key RTKs controlling HSPCs. Ubiquitination and dephosphorylation are two important mechanisms to negatively regulate RTK signaling (Dikic and Giordano, 2003; Sastry and Elferink, 2011). These data are in agreement with observations made in CBL and Itch knoc

cpi-613 br Results br Discussion In this study we provide

2018-10-20

Results Discussion In this study we provide several lines of evidence that Dnd serves as a critical PGC specifier in medaka. First, dnd knockdown is capable of specifically and completely abolishing PGC formation and its overexpression is sufficiently capable of inducing ectopic PGCs in embryo

br Results br Discussion The

2018-10-20

Results Discussion The range of cell types in Haemopedia makes identification of lineage-specific genes more rigorous. The genes that we have identified as lineage signatures are highly specific to each lineage and are lineage specific in other datasets (Figure S5). This provides a powerful re

Hello world!

2018-07-29