• Crystal structures of various CRM complexes have provided

  2019-07-02

  

  Crystal structures of various CRM1 complexes have provided insight into molecular details of the interactions between CRM1 and its interaction partners during the transport cycle. CRM1 cooperatively binds RanGTP and cargo in the nucleus (Paraskeva et al., 1999). In this ternary complex, RanGTP is l

• In rats exposed to day of nicotine withdrawal h

  2019-07-02

  

  In rats exposed to 1 day of nicotine withdrawal (24 h after the last nicotine administration) we expected a decrease of general locomotor activity and a decrease of global striatal dopamine release, which were assessed in a previous study following 14 days of nicotine exposure and 24 h of nicotine w

• According to this theory the chemical

  2019-07-02

  

  According to this theory, the chemical potential of the basic hydrate in the equilibrium condition can be calculated as: , and denote the chemical potentials of the basic hydrate, water and gas, respectively. Also, is the number of gas molecules per water molecules in the basic hydrate. After su

• In this paper we focused

  2019-07-02

  

  In this paper, we focused on Ewing sarcoma (ES), a rapidly growing, highly malignant bone tumor developing metastases in the vast majority of patients unless multiagent chemotherapy is applied [16]. ES is the second most frequent bone tumor in childhood and adolescence, and is characterized by the p

• The defining molecular feature of Ewing sarcoma is the

  2019-07-02

  

  The defining molecular feature of Ewing sarcoma is the characteristic EWSR1/ETS fusion protein, most commonly involving EWSR1 and FLI1 (Delattre et al., 1992, May et al., 1993). EWS–FLI1 causes global changes in gene expression both by directly regulating gene expression and by causing changes in ch

• Mammalian cells contain significant amounts of a relatively

  2019-07-02

  

  Mammalian cells contain significant amounts of a relatively lesser known enzyme that shows marked specifity for ether lipids containing AA and other 20–22 carbon fatty acids. This enzyme is called CoA-independent transacylase (CoA-IT), and transfers polyunsaturated moieties of 20–22 carbons, typical

• In addition to providing substantial insight

  2019-07-02

  

  In addition to providing substantial insight into substrate recognition, structural studies have revealed important details about mechanisms of glycosylation and HCF-1 cleavage [28,30,33]. Activation of the nucleotide-sugar is accomplished through interactions of the β-phosphate with the N-terminus

• Inflammatory action of certain cytokines

  2019-07-02

  

  Inflammatory action of certain cytokines can influence cell proliferative routes (Deshmane et al., 2009). When mTOR is inhibited, for instance by the action of Rapa, TGF-β1, which has an anti-inflammatory action, is increased. The relationship between high levels of TGF-β1 and Paclitaxel arrest has

• br Method Detailed study protocol was reported previously Th

  2019-07-01

  

  Method Detailed study protocol was reported previously. The ULTIMATE- HFrEF trial was approved by the Institutional Review Board of our hospital, and the study drug, udenafil, was approved as Investigational New Drug for treatment in patients with chronic HFrEF by Ministry of Food and Drug Safety

• Fischer and colleagues also raise concerns about the fact th

  2019-07-01

  

  Fischer and colleagues also raise concerns about the fact that MHSP “only offers testing to men”. As previously stated, MHSP is a public health programme based on the principles outlined in WHO\'s interim guidelines. The focus of that guidance is preventing sexual transmission of Ebola virus by men

• Different from our study results

  2019-07-01

  

  Different from our study results, a Korean study that enrolled 3827 patients showed that PC and MS were associated in women only. The possible explanations for this discrepancy were different population composition and a larger sample size compared with our current study. Also, our study showed that

• Education is part of the foundation for

  2019-07-01

  

  Education is part of the foundation for a successful ASP. A well-designed educational program provides prescribers with updated knowledge on antimicrobial use, drug resistance, and infectious disease management. Educational interventions have been shown to improve prescribing competency, change pres

• p-Cresyl sulfate Introduction Radiofrequency catheter ablati

  2019-07-01

  

  Introduction Radiofrequency catheter ablation (RFCA) has been established as an effective and safe non-pharmacological therapy for arrhythmias [1]. Idiopathic left ventricular outflow tract ventricular arrhythmias (LVOT-VAs) arising from the LVOT are rare compared with VAs arising from the right ve

• Based on our subgrouping according to ECG patterns

  2019-07-01

  

  Based on our subgrouping according to ECG patterns, men were predominant in the Br, ER, or Br–ER group compared with the true IVF group (Table 1). This sex difference was also noted in previous reports [15–17] and may be partially due to different levels of Ito channel expression between sexes [18].

• Introduction Lung cancer is the most common and deadly

  2019-07-01

  

  Introduction Lung cancer is the most common and deadly malignancy in Taiwan, the cause of an estimated 33,919 new cases between 2002 and 2008. Although the 5-year survival rate is only 15.9%, the overall survival rate is as high as 60.7% in patients whose tumors are confined to the primary site at

15930 records 1000/1062 page Previous Next First page 上5页 9969979989991000 下5页 Last page